Searchable abstracts of presentations at key conferences in endocrinology

ea0026p346 | Obesity | ECE2011

AM251, a CB1 receptor antagonist, increases GLUT4 expression in adipocytes

Furuya D T , Poletto A C , Freitas H S , Machado U F

Evidences have suggested that the endocannabinoid system is overactive in obesity, resulting in enhanced endocannabinoid levels in both circulation and visceral adipose tissue. The cannabinoid CB1 receptor is expressed in the adipose tissue besides the brain. Few studies in vitro suggest that CB1 activation increases glucose uptake in adipocytes. The objective of the present study was to investigate the CB1 receptor modulation on glucose transporter GLUT4 expression, which is ...

ea0026p735 | Diabetes (epidemiology, pathophysiology) | ECE2011

Insulin restores salivary secretion in diabetic rats: involvement of Na+/glucose cotransporter SGLT1

Sabino-Silva R , Campello R S , Nakamura H K , Freitas H S , Okamoto M M , Mori R C , Machado U F

Introduction: Considering the high capacity of water transport of Na+/glucose cotransporter SGLT1, the aim of this study was to investigate the potential role the SGLT1 in luminal membrane of ductal cells of salivary glands upon the non-stimulated salivary secretion of diabetic rats. The present study also investigates the presence of glucose transporter GLUT1 in salivary glands of rats.Methods: Non-stimulated salivary secretion and SGLT1/GLUT1 protein (...